Given the increasing levels of heavy metal pollution and its impact on the environment, the aim of this study was to evaluate the bioaccumulation of heavy metals (mercury, zinc, and nickel) in the soft tissues (muscle and hepatopancreas) of the blue swimming crab (Portunus segnis) along the Makran coast (Beris, Pozm, and Tis). Eighteen crab samples and nine surface sediment samples were collected in winter 2020, and the concentrations of mercury, zinc, and nickel in the hepatopancreas and muscle tissues of the crabs and sediment samples were measured using atomic absorption spectrophotometry. In all three stations, zinc concentration in the hepatopancreas was higher than in the muscle, with a significant statistical difference between all stations (P<0.05). The overall mean concentrations of mercury, zinc, and nickel in the hepatopancreas were 0.85±0.7, 240.81±101.41, and 69.24±33.58 mg/kg, respectively, and in the muscle, they were 0.37±0.04, 78.45±14.02, and 33.01±9.12 mg/kg, and in the sediment, they were 0.96±0.6, 26.4±14.45, and 21.49±6.21 mg/kg. The pattern of heavy metal accumulation in the tissues and sediment followed the order of Hg < Ni < Zn. Comparing the concentrations of metals in the muscle of the blue swimming crabs from the studied area with international standards (UK MAFF, FDA, NHMRC, WHO, and FAO) showed that the mercury concentration was below the NHMRC standard and close to other standards, the zinc concentration exceeded the permissible limits of only some standards, and the nickel concentration was below the permissible limits set by the FDA. Therefore, the consumption of the crab meat studied may be harmful to health due to mercury and especially zinc. Comparing the mean concentrations of heavy metals in the sediment samples from the stations with sediment quality standards showed low concentrations of zinc, nickel, and mercury.